Sustalad (Sustanon) Driada Medical 250 mg/ml

Sustalad 250 mg/ml (Sustanon)

Testosterone is an essential sex hormone in both men and women, playing a vital role in the development of reproductive tissues, muscle and bone mass, body hair, and overall well-being. It is widely recognized for its anabolic properties, promoting muscle growth, protein synthesis, and muscle glycogen storage. Testosterone is crucial for maintaining health and preventing conditions such as osteoporosis. While testosterone is commonly associated with muscle building and athletic performance, it is also used in medical treatments for gender dysphoria, male hypogonadism, and some types of breast cancer.

Mechanism of action

Testosterone binds to androgen receptors and serves as a precursor to dihydrotestosterone (DHT), a biologically active androgen formed through the action of the enzyme 5α-reductase on testosterone. DHT exhibits a higher binding affinity for androgen receptors. These hormone-receptor interactions trigger changes in gene activity within cells, leading to androgenic effects. Testosterone can also convert to estrogen through aromatization, although it is primarily estrogen, rather than testosterone itself, that regulates the hypothalamic-pituitary-testicular axis and suppresses endogenous testosterone production when exogenous testosterone is administered.

Medical Use

Testosterone is included on the World Health Organization’s List of Essential Medicines and is used in hormone replacement therapy (HRT) and testosterone replacement therapy (TRT). It is used to treat gender dysphoria, male hypogonadism, and some cases of breast cancer. Age-related declines in testosterone levels require HRT or TRT to maintain overall health and quality of life. Testosterone deficiency in men can lead to frailty, bone loss, and other abnormalities. It also affects cognitive functions, such as mood, spatial ability, attention, and memory, and can increase the risk of cognitive decline and dementia.

Testosterone for seniors

Men over 35 who experience reduced well-being are often advised to check their blood testosterone levels. If levels fall below 12 nmol/L, hormone replacement therapy is recommended. This approach offers several benefits, including improved body composition with increased muscle mass and reduced fat, rejuvenating effects, and improved sexual function. It is essential to monitor lipid profiles, blood parameters, and hormone levels during therapy. For those seeking to conceive, additional gonadotropin therapy may be necessary, as testosterone therapy suppresses natural gonadotropin production.

Testosterone in sport

Testosterone is favored by athletes and bodybuilders for its ability to increase muscle mass and strength. It exhibits both anabolic and androgenic effects, binding to androgen receptors to activate gene expression and promote muscle growth. Testosterone also enhances regeneration processes, increases oxygen capacity and nitric oxide production, and has a positive impact on endurance and athletic performance. It is commonly used in sports at doses ranging from 250-500 mg per week, with adjustments based on individual factors such as body weight and response. Aromatase inhibitors are often used to mitigate estrogenic side effects.

Dosages

• Beginners: 250 mg per week
• Average dosage: 300-750 mg per week
• High dosage: 750+ mg per week

Effects

• Increased muscle mass
• Development of male sexual characteristics
• Improved spermatogenesis and male behavior
• Burn fat
• Increased strength
• Increased libido
• Reduced blood cholesterol levels
• Lower risk of cardiac ischemia and coronary artery disease
• Stimulation of erythropoiesis and redistribution of subcutaneous adipose tissue
• It influences nitrogen and phosphorus metabolism

Side Effects

• Increased blood pressure
• Increased sexual behavior
• Hemoconcentration (blood clotting)
• Potential for blood clots in arteries and veins
• Water retention (edema)
• Masculinization
• Aggression, agitation, irritability
• Alopecia (baldness of the scalp)
• Acne
• Insomnia (rare)

Profile

• Half-life: 7-15 days
• Frequency of injections: 4-7 days

Pharmaceutical Form

• Oily solution for intramuscular injection.

Contraindications

• Pregnancy
• Known or suspected prostate or breast cancer
• Breastfeeding
• Hypersensitivity to the active substance or to any of the excipients

Conservation

• Do not use after the expiration date
• Store at temperatures between 8ºC and 30ºC
• Avoid freezing
• Protect from light