T4 Euthymed (Levothyroxine Sodium) Driada Medical

T4 Euthymed 50 mcg (Levothyroxine Sodium)

Levothyroxine is a synthetic form of thyroxine (T4), an endogenous hormone secreted by the thyroid gland, which is converted to its active metabolite, L-triiodothyronine (T3). T4 and T3 bind to thyroid receptor proteins in the cell nucleus and cause metabolic effects through the control of DNA transcription and protein synthesis. Like its naturally secreted counterpart, levothyroxine is a chiral compound in the L-form.

Purpose of use

Levothyroxine is a medication used to treat underactive thyroid (hypothyroidism) and other conditions in which a person’s thyroid hormone production is below normal. Levothyroxine sodium replaces or supports thyroid hormone, which is normally produced by the thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is damaged by radiation, medications, or removed by surgery. Levothyroxine is also known as L-thyroxine or T4.

Enhanced Metabolism

By normalizing thyroid function, Levothyroxine Sodium helps maintain a healthy metabolism, crucial for effective fat loss and muscle gain.

Increased Energy Levels

Proper thyroid function can lead to improved energy levels, providing the stamina and endurance needed for rigorous training sessions.

Improved Muscle Recovery

Balanced thyroid hormones can aid in protein synthesis and muscle repair, crucial for bodybuilders during the recovery phase.

Weight Management

By regulating the metabolism, this drug helps maintain a healthy weight, a key factor in bodybuilding for aesthetic and performance goals.

Consistent Performance

Stable thyroid levels ensure consistent physical and mental performance, essential for athletes who must maintain a high level of intensity in training.

Use with Growth Hormone

Patients receiving Human Growth Hormone (HGH) should take T4 to prevent T4 deficiency, as growth hormone significantly increases the conversion of T4 to T3, which can cause pathological T4 deficiency.

Dosage and Administration

It is recommended to take Levothyroxine on an empty stomach about half an hour to an hour before meals to maximize absorption. Patients are also advised to take the tablet with a glass of water to facilitate swallowing and aid in dissolution. Dosages vary based on the patient’s age, body weight, and individual condition, as well as medication and diet compliance. The maximum dosage can reach 300-400 mcg per day, but this is rare. Most people should be careful to start with a low dose and consult a doctor to determine the optimal dose.

How to Use

Essentially, the dosage starts at 25-50 mcg per day and increases by 25-50 mcg per day every 5-6 days. The maximum is 300-400 mcg per day. Spread a few tablets throughout the day. The maximum cycle lasts seven weeks. At least six weeks should elapse between cycles. It will also restore your thyroid gland to normal function. It is commonly combined with Clenbuterol to make both even more effective at burning fat.

Average dosage: 100 to 200 mcg per day Effective dosage: pyramid method Tested cycle: 5-6 weeks

Pharmacokinetics

The absorption of orally administered levothyroxine ranges from 40 to 80%, with most of the drug absorbed from the jejunum and upper ileum. Levothyroxine absorption is increased by fasting and decreased in certain syndromes, by certain foods, and with age.

The elimination half-life is 6-7 days for people with normal laboratory results; 9-10 days for people with hypothyroidism; and 3-4 days for people with hyperthyroidism. Thyroid hormones are eliminated primarily by the kidneys (about 80%), with urinary excretion decreasing with age. The remaining 20% ​​of T4 is eliminated in the feces.

Effects

• Regulate your metabolism
• Fat Burner
• Increases anabolic processes and muscle growth
• Central nervous system stimulation

Side Effects

Allergies to the drug are unlikely, but if a patient develops a serious reaction to this drug, such as difficulty breathing, shortness of breath, or swelling of the face and tongue, it is imperative that the patient seek immediate medical attention. Adverse events are generally caused by incorrect dosages. Side effects from excessive doses include weight loss, difficulty tolerating heat, sweating, anxiety, difficulty sleeping, tremors, and rapid heartbeat. Use is not recommended in people who have had a recent heart attack. Use during pregnancy has been shown to be safe. An acute overdose can cause fever, hypoglycemia, heart failure, coma, and unrecognized adrenal insufficiency. A massive acute overdose can be life-threatening; treatment should be symptomatic and supportive. A massive overdose may require beta-blockers for increased sympathomimetic activity. Side effects of overdose appear 6 hours to 11 days after ingestion.

• Chest pain, discomfort, or tightness
• Difficulty swallowing
• Extreme fatigue
• Fainting Fast, slow, irregular, pounding or racing heartbeat
• Heat intolerance
• Nausea
• Sweating
• Tremors

Profile

• Half-life: 6-24 hours
• Frequency of intake: 1-2 times a day

Precautions

Prolonged use of high doses can cause serious thyroid problems and suppress endogenous hormone production. Studies show up to a 20% decrease in endogenous production after 3 weeks of use. However, when used correctly at the recommended doses, thyroid function returns after 3–4 weeks. Levothyroxin has effects similar to adrenaline, including increased heart rate and nervousness, which could be avoided by using beta-blockers.

Contraindications

Levothyroxine is contraindicated in people with hypersensitivity to levothyroxine sodium or any component of the formulation, in people with acute myocardial infarction, and in people with thyrotoxicosis of any etiology. Levothyroxine is also contraindicated in people with uncorrected adrenal insufficiency, as thyroid hormones can cause acute adrenal crisis by increasing the metabolic clearance of glucocorticoids.

Drug Interactions

There are also foods and other substances that can interfere with the absorption of thyroxine replacement. Avoid taking calcium and iron supplements within 4 hours of the medication and avoid taking soy products within 3 hours of the medication, as these can reduce its absorption. Other substances that reduce absorption include antacids containing aluminum and magnesium, simethicone or sucralfate, cholestyramine, colestipol, and Kayexalate.

Other substances cause other adverse effects that can be serious. Ketamine can cause hypertension and tachycardia, and tricyclic and tetracyclic antidepressants increase its toxicity. Lithium, on the other hand, causes hyperthyroidism by affecting the thyroid’s iodine metabolism and thus also inhibits synthetic levothyroxine.

Special Warnings

Levothyroxine sodium should be introduced very gradually in patients over 50 years of age and in those with long-standing hypothyroidism to avoid sudden increases in metabolic demands. Patients with panhypoppituitarism or other predisposing causes of adrenal insufficiency may react to levothyroxine treatment, and it is advisable to initiate corticosteroid therapy before administering levothyroxine to these patients. Levothyroxine sodium should be used with caution in patients with cardiovascular disorders, including angina, coronary artery disease, and hypertension, and in the elderly, who are more likely to have occult heart disease.

Contraindicated in patients with untreated subclinical thyrotoxicosis (suppressed serum TSH levels with normal T3 and T4 levels) and in patients with acute myocardial infarction. Thyroid replacement therapy may increase insulin or other antidiabetic treatment (such as metformin) requirements. Caution is warranted in patients with diabetes mellitus and diabetes insipidus. Subclinical hyperthyroidism may be associated with bone loss. To minimize the risk of osteoporosis, levothyroxine sodium dosage should be titrated to the lowest possible effective level.

Conservation

• Keep out of reach of children
• Store in a cool, dry place, away from direct sunlight
• Store at room temperature
• Do not use after the expiration date